
Press Release · Health Policy Podcast
The Human and Economic Toll of Treatment-Resistant Depression
Published · Featuring Mark Desmarais of Health Management Associates
WASHINGTON — June 23, 2026 — Mark Desmarais, a principal at Health Management Associates, joined the Health Policy Podcast to discuss the implications of treatment-resistant depression (TRD) on patients and the healthcare system. The episode explores new research on the economic burden of TRD, highlighting its impact on Medicare and the urgent need for effective treatments.
Desmarais presented findings from a recent report that analyzed Medicare claims data, revealing that individuals with TRD incur approximately $8,000 more in healthcare costs annually compared to those whose depression is well managed. The discussion also included insights from Dr. William Sauvé, Chief Medical Officer at Osmind, who emphasized the chronic nature of TRD and its associated cognitive impairments.
The rising prevalence of treatment-resistant depression and its significant economic toll on the healthcare system underscore the need for improved treatment strategies. As more patients seek mental health care, addressing TRD effectively could alleviate both human suffering and financial strain on healthcare resources.
“Individuals with TRD cost the system about $8,000 more each year than those patients whose depression is well managed,” said Mark Desmarais. “This has a human impact, but it's also an economic impact, and that should incentivize everyone to really work harder to solve this problem.”
The conversation highlights the importance of timely and effective interventions for TRD, advocating for a shift in treatment approaches to better serve patients and reduce costs in the long run.
About Health Management Associates
Founded in 1985, Health Management Associates (HMA) is a national healthcare consulting and research firm that works with government agencies, health systems, health plans, providers, foundations and community organizations. The company provides policy analysis, strategic consulting, data analytics and program evaluation services focused on improving healthcare delivery and outcomes. HMA employs hundreds of consultants, analysts, clinicians and policy experts across the United States. The firm is particularly known for its expertise in Medicaid, Medicare, behavioral health, public health, long-term care, value-based payment models and healthcare financing. In addition to its consulting practice, HMA publishes research, policy analyses and market intelligence on emerging healthcare issues. The firm’s experts frequently advise state and federal policymakers, healthcare organizations and industry stakeholders on topics ranging from healthcare access and affordability to payment reform and care delivery innovation. HMA’s clients include state Medicaid agencies, federal health programs, hospitals, physician organizations, health insurers, behavioral health providers and nonprofit organizations. The firm has played a role in evaluating and designing healthcare programs affecting millions of Americans through both public and private healthcare systems.
About the Guest

Mark Desmarais — Principal
Mark Desmarais specializes in Medicare and Medicaid policy consulting with a focus on large dataset analysis, including all Medicare datasets available to the private sector. He is a front-to-back problem solver for clients designing data analysis who strives to answer questions and anticipate future needs. Mark has extensive experience analyzing Medicare and other health datasets and applying the results in solving public policy challenges and supporting policy advocacy in the regulatory and legislative arena. Before joining HMA, Mark was a partner at The Moran Company, now an HMA Company. He manages project teams tackling policy issues across the healthcare spectrum. He has extensive experience helping pharmaceutical companies and device manufacturers as they navigate the regulations surrounding the Outpatient and Inpatient Prospective Payment Systems. He has performed in-depth modeling of issues related to the 340B program as well. In addition, Mark has vast experience with regulatory issues in ambulatory surgical centers, dialysis facilities, and skilled nursing facilities. He has led modeling of the Merit-based Incentive Payment System (MIPS) scoring proposals advanced by the Centers for Medicare & Medicaid Services (CMS) in implementing the Medicare Access & CHIP Reauthorization Act (MACRA). In addition, Mark has analyzed client data warehouses to inform public policymaking on issues where publicly available datasets lacked essential information. He manages client relationships and deliverables, leads small project teams, and trains analysts in programming, policy context, and data analysis. His clients have included pharmaceutical, biotech, and device manufacturers, trade associations, hospitals, and physician specialty societies. Mark graduated from the University of Chicago with a bachelor’s degree in mathematics. He has more than 10 years of SAS® programming experience with large healthcare datasets.
About the Health Policy Podcast
The Health Policy Podcast hosts conversations on energy, infrastructure, policy and economic growth — interviewing the operators, regulators, and innovators powering America's grid, gas, nuclear, and industrial future. Subscribe on Apple Podcasts and Spotify.
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